CellPly announces acceptance of one abstract at the CICON23 conference

BOLOGNA, Italy, September 18, 2023 – CellPly, the pioneer in multiparametric single-cell analysis and automated potency testing for cell therapy, today announced that it will present data in a poster presentation at the Seventh International Cancer Immunotherapy Conference: Translating Science into Survival, being held in Milan, Italy, on Sep. 20-23, 2023.

The data reported in this abstract, generated within a scientific collaboration with the team of Dr. Richard Harbottle at the DKFZ institute, Heidelberg, Germany, show the characterization of TCR-T cells engineered from Dr. Harbottle’s team through the VivaCyte® technology for the analysis of cell function at the single-cell resolution developed at Cellply. Thanks to a novel single-cell serial killing assay, researchers were able to demonstrate that T cells engineered with a non-viral DNA nanovector acquire the capacity to exert their cytotoxic function multiple times before their exhaustion, leading to an increase in T cell potency.

Details of the poster presentation are as follows:

Title: Single-cell cytotoxicity analysis identifies serial killer transgenic TCR-T cells manufactured using non-viral S/MAR DNA nanovectors
Abstract number: P528
Session: POSTER SESSION A – EVEN NUMBERS Thursday, Sept. 21
Link to abstract

About Cellply
CellPly is a life-science company developing analytical tools aiming at unraveling the complexity of the immune system and enabling rapid and effective development of next-generation immunotherapies and cell-based therapies. Our unique solution combines a proprietary microfluidic technology to capture functional and phenotypic information from thousands of single cells, with the highly automated VivaCyte® analytical instrument, integrating robotic solutions and AI for image analysis. Our goal is to make in-depth analysis applicable across the therapy development cycle, from discovery to process development and quality control.


Follow us
LinkedIn: https://www.linkedin.com/company/cellply
Twitter: https://twitter.com/cellply

Cellply to present new method for evaluating immunotherapy efficacy at the 61th ASH Annual Meeting

Bologna (Italy), 25 November 2019.

Cellply announced today that the company will present an abstract with new results about its novel Inter-Cell Networking Profiling (ICNP) technology at the 61th Annual Meeting and Exposition of the American Society of Hematology (ASH), on December 7-10 in Orlando, FL, USA.

“There is an unmet need in oncology to expand current precision medicine approaches to cancer immunotherapy” says Massimo Bocchi, CEO at Cellply. “The work we will present at the next ASH congress represents an important step forward in the combined evaluation of drug action and immune system activity. Our work, leveraging on our unique ability to generate thousands of microtumors in a single automated test and select the cell networks better mimicking the in-vivo cell behavior, provides an unprecedented method to screen antibody therapies with immune-mediated mechanisms of action. Starting from these results we are currently working with biopharmaceutical companies and research institutes to generate novel and effective immuno-oncology therapeutics”.

The abstract is the results of a scientific collaboration with hematologists and scientists from Prof. Cavo’s team working on Multiple Myeloma at Seragnoli Institute of Sant’Orsola Polyclinic in Bologna (Italy). The work is supported by the ONCOSMART project, funded by the European Commission under the SME Instrument (Phase 2) programme.

Title: Inter-Cell Networking Profiling Enables Comprehensive Characterization of Immune-Mediated Activity of Anti-CD38 Therapy through Ex-Vivo Analysis of Multiple Myeloma Patients
Authors: Alice Bettelli, Rita Ruggiano, Silvia Bocchi, Laura Rocchi, Andrea Faenza, Enrica Borsi, Carolina Terragna, Elena Zamagni, Marina Martello, Marco Bettelli, Laura Rambelli, Viviana Guadagnuolo, Nicola Pecorari, Luca Giulianelli, Matteo Pisani, Dario Biscarini, Michele Cavo, Roberto Guerrieri and Massimo Bocchi
Abstract ID: 3372
Date/Time: Sunday, December 8, 2019, 6:00 PM-8:00 PM
Location: Hall B, Level 2 (Orange County Convention Center)
Session: 803. Emerging Diagnostic Tools and Techniques: Poster II

Link to abstract

Download poster

Cellply invited to present at the World Health Summit 2019

Cellply has been invited to present its innovation at the World Health Summit which will be held in Berlin on October 27-29, 2019.

The World Health Summit is one of the world’s leading conferences on global health issues bringing together researchers, physicians, key government officials, and representatives from industry, NGOs and healthcare systems to improve health globally.

Cellply will take part to the Entrpreneurs in Global Health program where a handful of top-rated startups have the opportunity to present their innovative ideas for future healthcare to international experts.

The World Health Summit is promoted under the auspices of Chancellor Angela Merkel, French President Emmanuel Macron and the President of the European Commission. The World Health Summit was founded in 2009 at the Charité. This year, 300 speakers and 2,500 participants from 100 nations are expected, including more than 10 ministers from around the world, top scientists, business and civil society leaders, WHO chiefs and World Bank vice-president.

Date of presentation: Monday, 28/10/2019, between 12:45-13:45
Venue: Kosmos | Karl-Marx-Allee 131a, Berlin

Cellply wins the €300k Gaetano Marzotto prize and Unicredit StartLab prize

ROME, ITALY, November 22, 2018:

Cellply has been awarded with the prestigious Gaetano Marzotto prize and received an €300,000 grant and an assistance programme from the CUOA Business School. The award ceremony was held at the MAXXI museum in Rome. The Company Prize awarded to Cellply comes after a tough selection process, as more than 600 companies applied to the competition.

During the ceremony, Cellply was also awarded with the Unicredit StartLab Special Prize, a programme providing coaching, training and support to high-tech startup companies.

The jury selected Cellply for the motivation, high competence and commitment of its team having the ambition to make a change in the way cancer patients are treated worldwide and in speeding up the drug development process. The project, if successful, will have the potential to demonstrate the quality and value of Italian research and entrepreneurship.

Cellply develops an innovative in-vitro diagnostic system to predict the efficacy of anticancer drugs with a personalized test that analyzes the in-vitro drug response of living cells quickly obtained from patient biopsies.

The Gaetano Marzotto prize, at its 8th edition, aims at looking for new business people and builders of the future who are able to combine innovation, business and social impact.

Cellply selected as finalist at Lyfebulb Oncology Award


Lyfebulb, a patient empowerment platform that connects patients, industry and investors to support user-driven innovation in chronic diseases, and Helsinn, with activities focused on early-stage investments in areas of high unmet patient need, have announced today that Cellply has been selected as one the eleven finalist companies for the Lyfebulb-Helsinn Innovation Summit & Award in Oncology. The Lyfebulb-Helsinn Innovation Summit & Award final event will be hosted on 26-27 March 2018, by Lyfebulb and Helsinn at the Monte-Carlo Bay Hotel and Resort, in Monaco, Principality of Monaco.

Read the full story here

Cellply abstract accepted at the AACR 2018 Annual Meeting

Bologna (Italy), 4 February 2018

Cellply will present results of clinical testing activities on Acute Myeloid Leukemia patients at the American Association for Cancer Research (AACR) 2018 Annual Meeting, taking place April 14-18 in Chicago.

Results of the study, conducted in collaboration with haematologists and researchers at the Sant’Orsola-Malpighi Polyclinic in Bologna, show the high accuracy obtained with Cellply’s platform in predicting standard therapy outcome.

Title: Lab-on-a-chip-based in-vitro functional profiling proves to be effective in predicting therapy outcome in AML patients
Authors: Laura Rocchi, Andrea Faenza, Laura Rambelli, Viviana Guadagnuolo, Giovanni Marconi, Giorgia Simonetti, Cristina Papayannidis, Antonella Padella, Nicola Pecorari, Luca Giulianelli, Dario Biscarini, Giovanni Martinelli, Roberto Guerrieri and Massimo Bocchi
Abstract ID: 3613
Date/Time: Tuesday Apr 17, 2018 8:00 AM – 12:00 PM
Location: McCormick Place South, Exhibit Hall A, Poster Section 25
Session Category: Clinical Research
Session Title: Biomarker Discovery 4

Link to abstract

View poster online

Cellply and Sant’Orsola-Malpighi Polyclinic to present one abstract on AML patient stratification with the Open Microwell platform at the 58th ASH Annual Meeting

Bologna (Italy), 4 November 2016.

Cellply announced today that the results of a scientific collaboration with hematologists at Seragnoli Institute of Sant’Orsola Polyclinic in Bologna (Italy) working on Acute Myeloid Leukemia (AML), a group led by Prof. Giovanni Martinelli, will be presented at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), on December 3-6 in San Diego, CA, USA. “This is a key milestone for our company as it shows the potential of the Open Microwell technology and the IVD platform under development at Cellply to become an important tool for guiding the identification of the appropriate treatment for each patient or patient set through the analysis of biological information that today remain mostly not exploited for patient stratification”, says Massimo Bocchi, CEO of Cellply. “The preliminary data collected within this scientific activity provided good correlation between our test and the clinical outcome, making Cellply’s platform promising for predicting the haematological response, an endpoint of primary importance not only from a clinical standpoint but also for its use within clinical trials”, added Laura Rocchi, Head of Biology at Cellply. The following abstract was accepted for poster presentation by the American Society of Hematology.

Title: Ex-Vivo Drug Response Profiling for Precision Medicine Approaches in Acute Myeloid Leukemia with the Open Microwell Microfluidic Platform
Authors: Laura Rocchi, Andrea Faenza, Laura Rambelli, Viviana Guadagnuolo, Giovanni Marconi, Giorgia Simonetti, Cristina Papayannidis, Antonella Padella, Nicola Pecorari, Luca Giulianelli, Dario Biscarini, Giovanni Martinelli, Roberto Guerrieri and Massimo Bocchi
Abstract ID: 1675
Date/Time: Saturday, December 3, 2016, 5:30 PM-7:30 PM
Location: Hall GH (San Diego Convention Center)
Session: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster I

Link to abstract on Blood Journal