One cell, one instrument, many assays

Functional profiling at single cell resolution within a heterogeneous cell population offers a unique signature into cellular interactions. Single cell functional analysis  enables the stratification of data from many assays from each immunophenotype in a time lapsed data output. 

Meet the Vivacyte™ platform

A fully automated immunotherapy assay platform with applications spanning R&D through manufacturing   

Co-Culture Array Chip

VivaCyte Instrument

AI-Based Image Analysis

CO-CULTURE ARRAY (CC-Array™) CHIP

  • Generate 19,000 co-cultures with varying E:T
  • 16  separate experiments per chip
  • Up to 8 chips per experiment
  • Rapid  perfusion of wells

Rapid liquid exchange

The Open Microwell technology enables replacement of media in microchannels and in each 0.5nL microwell without displacing cells previously loaded. This powerful feature allows instantaneous resuspension of cells in new fluids. Multiple media and reagents can be sequentially loaded to implement an endless number of assays on the same cells.

VIVACYTE INSTRUMENT

A “Lab In a Box” with a fully contained robotic platform with image analysis and environmental control

Incubation

Incubation
Control of temperature, CO2 level and humidity

Hi-content-imaging

High-content imaging
Brightfield + up to 8 fluorescence channels

Robotics

Robotics
Chip and plate handling, tube de-capping, barcode

liquid-handling-chip_300px

Liquid handling
Sample / reagent mixing, chip loading, disposable tips

Analytical Software

A suite of software tools allows you to analyze single-cell data or compare varying E:T in relation to serial killing, cytotoxicity, cytokine release and other intracellular assays as they occur in a given immunophenotype. All within one experiment

Analytical interface

AI-assisted cell detection and classification, followed by powerful dashboard enable deep single-cell multiplex and time-lapse analytics at your fingertips

Co-culture screener

In a few clicks select hundreds to thousands of co-cultures with similar patterns (e.g. single immune cells surrounded by a specific range of target cells)

Serial killing analysis

Measure serial killing with single-cell resolution and in time lapse. Compare multiple donors or multiple gene edit based on quantitative analysis

Multiple E:T analysis

Cluster data based on cell-cell interaction patterns and compare functional readouts at multiple effector : target ratios with just one single microfluidic channel